Endocrine Abstracts

Based on the known oxidative stress of nicotine, we examined the effects of Ucn I on nicotine-induced oxidative stress in HL-1 cardiomyocytes. HL-1 cardiomyocytes is plated on 96-well plate at a density of 2.0×104 cells/well with Claycomb medium containing 10% fetal bovine serum (FBS) and 0.1 mmol/L epinephrine. After starvation of FBS and epinephrine with Claycomb medium, cells were stimulated with or without (+/−)-nicotine, Ucn I and Ucn II. Cells were ...

A 81-year-old woman came to our hospital with complaints of reduction in appetite and weakness of lower limbs. She had developed Cushing’s features. Initial laboratory evaluation revealed severe hypokalemia and hyperglycemia without ketoacidosis, and diabetes mellitus had not been detected previously. A series of hormonal assessment revealed marked ACTH-dependent hypercortisolism. Corticotrophin-releasing hormone stimulation test resulted in normal ACTH response, thus we ...

A 17-year-old male was referred to our hospital with lack of secondary sex characteristics. His voice didn’t break and he lacked of pubes and hircus. His bilateral testicular volume was small and his sense of smell was normal. There was no varicocele or pituitary adenoma. His chromosomal study showed no aberrations. Serum levels of LH, FSH, total testosterone and free testosterone were 1.05 mIU/ml, 1.68 mIU/ml, 0.26 ng/ml and <0.6 pg/ml respectively. A repeated GnRH t...

A 63-year-old woman was referred to our hospital for examination of three adrenal nodules. She had been diagnosed with hypertension since the age of 40 and prescribed antihypertensive drugs. Then, she was pointed out hypokalemia and bilateral adrenal tumors. She was diagnosed with primary aldosteronism (PA) at another hospital and had been prescribed spironolactone because the localization was not determined despite adrenal vein sampling (AVS) was performed.<p class="abste...

A 77-year-old female had a loss of appetite, severe fatigue and hyponatremia (127–135 mmol/l) for 2 months. She was diagnosed as depression, and was psychiatrically hospitalized. After admission, she was beginning to take antidepressants, but they did not work at all. To examine hyponatremia, endocrinological examination was done, then low plasma ACTH (2.0 pg/ml) and cortisol (1.3 μg/dl) was found. Brain MRI examination showed no remarkable findings in pituitary. We ...